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Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism

AUTHORS

Seyyed Hossein Fatemi 1 , * , Timothy D Folsom 2

AUTHORS INFORMATION

1 Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, MN 55455 USA, Minneapolis, United States

2 Departments of Pharmacology and Neuroscience, University of Minnesota Medical School, Minnesota, United States

How to Cite: Fatemi S H, D Folsom T. Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism, Iran J Psychiatry Behav Sci. 2010 ; 4(2):56-7.

ARTICLE INFORMATION

Iranian Journal of Psychiatry and Behavioral Sciences: 4 (2); 56-7
Published Online: December 31, 2010
Article Type: Brief Report
Received: August 13, 2010
Accepted: August 24, 2010

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Abstract

Autism and fragile X syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile X mental retardation protein (FMRP) in autism. We sought to measure protein levels of FMRP in the lateral cerebella of subjects with autism and matched controls. We found significantly reduced levels of FMRP (p<0.0063) in subjects with autism. The loss of FMRP expression in subjects with autism may help explain behavioral deficits, presence of seizure, and reduction in GABA receptors in subjects with autism.

Declaration of interest: None

Keywords

X Mental Retardation Autism

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