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Depot Typical Antipsychotics versus Oral Atypical Antipsychotics in Relapse Rate Among Patients with Schizophrenia: A Five -Year Historical Cohort Study

AUTHORS

Hamid-Reza Ahmadkhaniha 1 , * , Shahab Bani-Hashem 2 , Masoud Ahmadzad-Asl 3

1 Research Center, Tehran Psychiatry Institute, Tehran University of Medical Sciences and Health Services, Tehran, Iran

2 Psychiatrist, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences and Health Services, Kerman, Iran

3 Assistant Professor, Department of Psychiatry, Mental Health Research Center, Tehran Psychiatry Institute, Tehran University of Medical Sciences and Health Services, Tehran, Iran

How to Cite: Ahmadkhaniha H, Bani-Hashem S, Ahmadzad-Asl M. Depot Typical Antipsychotics versus Oral Atypical Antipsychotics in Relapse Rate Among Patients with Schizophrenia: A Five -Year Historical Cohort Study, Iran J Psychiatry Behav Sci. 2014 ; 8(1):66-71.

ARTICLE INFORMATION

Iranian Journal of Psychiatry and Behavioral Sciences: 8 (1); 66-71
Published Online: March 30, 2014
Article Type: Original Article
Received: February 04, 2012
Revised: September 23, 2013
Accepted: January 13, 2014

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Abstract

Objective: The present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, SDAs) and depot preparation of conventional (typical) antipsychotics.

Methods: In this historical cohort study, mean relapse per month (MRM) index, duration between initiation of antipsychotic treatment and the first relapse episode, and the time gap between successive relapses were compared between 84 patients on SDAs-except clozapine (group 1) and 81 others on depot typical antipsychotics (group 2).

Results: The two groups were comparable regarding mean (±SD) MRM index [0.033 (±0.004) in group1 and 0.044 (±0.05) in group 2; p = 0.345]. Mean (±SD) duration of time between initiation of maintenance treatment and the first relapse was 15.5 (±13.67) months in group 1 and 16.40 (±15.31) months in group 2, (p = 0.876). Mean (±SD) duration of remission periods between successive relapses were 17.92 (±14.2) and 15.8 (±16.9) months for group 1 and group 2, respectively (Mann-Whitney test, (p = 0.048).

Conclusion: Orally taken atypical antipsychotics were able to keep the duration of remission periods between successive relapses more prolonged compared to depot conventional preparations. This could be added to their other remarkable benefits especially if the patient is expected to experience multiple relapses.

Declaration of interest: None.

Citation: Ahmadkhaniha HR, Bani-Hashem Sh, Ahmadzad-Asl M. Depot typical antipsychotics versus oral atypical antipsychotics in relapse rate among patients with schizophrenia: A five- year historical Cohort study. Iran J Psychiatry Behav Sci 2014; 8(1): 66-71.

Keywords

Antipsychotic Agents Dopamine Receptor Antagonists Long-Acting Drugs Schizophrenia Serotonin Dopamine Antagonists

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