Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania

AUTHORS

Zahra Mirsepassi 1 , * , Robabeh Mazinani 2 , Farbod Fadai 2 , Neda Alibeigi 3 , Ali Nazeri-Astaneh 4

1 Resident, Razi Psychiatric Hospital, Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

2 Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

3 Clinical Psychologist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

4 Psychiatrist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

How to Cite: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania, Iran J Psychiatry Behav Sci. 2013 ; 7(2):11-5.

ARTICLE INFORMATION

Iranian Journal of Psychiatry and Behavioral Sciences: 7 (2); 11-5
Published Online: December 30, 2013
Article Type: Original Article
Received: February 28, 2013
Revised: March 30, 2013
Accepted: September 19, 2013

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Abstract

Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.

Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly.

Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks (p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709).

Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic.

Declaration of interest: None. Clinical Trial Registration: URL: http://www.irct.ir. IRCT201110317960N1.

Citation: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate add-on lithium carbonate for treatment of acute mania. Iran J Psychiatry Behav Sci 2013; 7(2): 11-5

Keywords

Lithium Topiramate Mania Treatment

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